The difference between MHC class 1 and MHC class 2 lies at the heart of how the immune system distinguishes between threats arising inside the body and those coming from the outside. MHC, or Major Histocompatibility Complex, molecules act as molecular billboards that display fragments of proteins—called peptides—on the surface of cells so that T cells can inspect them. Understanding how MHC class I and MHC class II differ is essential for medical students, immunology researchers, and anyone curious about how vaccines, organ transplants, and autoimmune diseases work.
What Is the Major Histocompatibility Complex (MHC)?
The Major Histocompatibility Complex is a group of genes that code for proteins responsible for antigen presentation. In humans, this complex is
